補體成分C9
Sign in to saveAlso known as C9, complement component 9, complement component C9
mammalian protein found in Homo sapiens
Protein · UniProt
Complement component C9
- Gene
- C9
- Organism
- Homo sapiens (Human)
- Length
- 559 aa
- Molecular mass
- 63,173 Da
- Evidence
- 1: Evidence at protein level
Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:39914456, PubMed:39814882, PubMed:9212048, PubMed:9634479). The comp…
Swiss-Prot (reviewed) · via UniProt
Research
2,062 papers- Complement.Annual review of biochemistry · 1975
- Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin.The Korean journal of parasitology · 2022
- Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly.Nature communications · 2026
- Reference typing report for complement components C6, C7 and C9 including mutations leading to deficiencies.Experimental and clinical immunogenetics · 1998
- Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae.mBio · 2025
via PubMed
Article · 中文
補體成分9（英語：Complement component 9）是與補體系統有關的一種蛋白質。它是補體膜攻擊複合物（MAC）家族的一員，能誘導細胞膜上孔洞的產生。
Abstract from DBpedia / Wikipedia · CC BY-SA