Structure via PubChem · Public domain (PubChem)
cp-809101
Sign in to saveCP-809101 is a drug which acts as a potent and highly selective serotonin 5-HT2C receptor full agonist. It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.
Chemical data
- Formula
- C15H17ClN4O
- Molecular weight
- 304.77 g/mol
- IUPAC name
- 2-[(3-chlorophenyl)methoxy]-6-piperazin-1-ylpyrazine
- SMILES
- C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
- InChIKey
- PCWGGOVOEWHPMG-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 50.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 304.109
Show 3 more facts
- canonical SMILES
- C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
- chemical formula
- C₁₅H₁₇ClN₄O
- Commons category
- CP-809101
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
CP-809101 is a drug which acts as a potent and highly selective serotonin 5-HT2C receptor full agonist. It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.
The drug has more than three orders of magnitude lower potency as an agonist of the serotonin 5-HT2A receptor compared to the serotonin 5-HT2C receptor as well as lower efficacy at the receptor in comparison ( = 93% and 67%, respectively). It did not produce the head-twitch response in rodents, and was able to antagonize the head-twitch response induce by the psychedelic drug (–)-DOI.
Excerpted from Wikipedia’s “cp-809101” article, available under the CC BY-SA 4.0 licence.