CPE

Name

carboxypeptidase E

Type

protein-coding

Position

165,361,194–165,499,352 (+)

Aliases

BDVS, CPH, IDDHH

Ensembl

ENSG00000109472

RefSeq RNA

NM_001873.4

RefSeq protein

NP_001864.1

This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

carboxypeptidase E

Symbol

CPE

Biotype

Protein coding

Organism

Homo sapiens

Location

4:165,361,194-165,499,352

Strand

Forward (+)

Assembly

GRCh38