CRELD2
Sign in to saveAlso known as cysteine rich with EGF like domains 2
Cysteine-rich with EGF-like domain protein 2 is a protein that in humans is encoded by the CRELD2 gene found on chromosome 22q13. It is a known homolog of CRELD1. CRELD2's identifying feature is a tryptophan-aspartic acid domain. It is a multifunctional glycoprotein that is approximately 60 kilodaltons and can reside in the endoplasmic reticulum (ER) or Golgi apparatus and be secreted spontaneously. It is implicated in numerous ER stress-related diseases including chronic liver disease, cardiovascular disease, kidney disease, and cancer.
Gene data
CRELD2- Name
- CRELD disulfide isomerase 2
- Type
- protein-coding
- Position
- 49,917,989–49,927,544 (+)
- Ensembl
- ENSG00000184164
- RefSeq RNA
- NM_001135101.3, NM_001284317.2, NM_001284318.2, NM_024324.5, NR_104295.2
- RefSeq protein
- NP_001128573.1, NP_001271246.1, NP_001271247.1, NP_077300.3, XP_005261794.1
Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
CRELD disulfide isomerase 2
- Symbol
- CRELD2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:49,917,989-49,927,544
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- exact match
- identifiers.org/ncbigene/79174
- HomoloGene ID
- 11526
- found in taxon
- Homo sapiens
- genomic end
- 50321188
- genomic start
- 50311815
- expressed in
- pylorus
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.33
Sources (3)
via Wikidata · CC0
~6 min read
Encyclopedic overview
12 sectionsContents
- Structure
- Function
- Tissue expression
- CRELD2 in diseases
- Chronic liver disease
- Chronic vascular diseases
- Cartilage and bone metabolism
- Cancer
- CRELD2 as a biomarker
- References
- Further reading
- External links
Cysteine-rich with EGF-like domain protein 2 is a protein that in humans is encoded by the CRELD2 gene found on chromosome 22q13. It is a known homolog of CRELD1. CRELD2's identifying feature is a tryptophan-aspartic acid domain. It is a multifunctional glycoprotein that is approximately 60 kilodaltons and can reside in the endoplasmic reticulum (ER) or Golgi apparatus and be secreted spontaneously. It is implicated in numerous ER stress-related diseases including chronic liver disease, cardiovascular disease, kidney disease, and cancer.
== Structure == thumb|Structure of CRELD2 CRELD2 can present itself in a variety of isoforms with similar motifs but different functions.. Common motifs include EGF/calcium binding EGF domains and furin cysteine-rich domains. The C-terminal of this protein includes the following specific amino acid sequence necessary for retention and secretion: (R/H)EDL. The N-terminal has multiple CXXC motifs which are vital for translocation and isomerase activity. CpG islands are present in the functional promoter region upstream of CRELD2. In this functional promoter region, GC nucleotides are abundant, and a TATA box is absent. An ERSE (ER Stress Responsible Element) is also present in CRELD2 and is conserved in numerous species.
Excerpted from Wikipedia’s “CRELD2” article, available under the CC BY-SA 4.0 licence.