Cysteine-rich with EGF-like domain protein 2 is a protein that in humans is encoded by the CRELD2 gene found on chromosome 22q13. It is a known homolog of CRELD1. CRELD2's identifying feature is a tryptophan-aspartic acid domain. It is a multifunctional glycoprotein that is approximately 60 kilodaltons and can reside in the endoplasmic reticulum (ER) or Golgi apparatus and be secreted spontaneously. It is implicated in numerous ER stress-related diseases including chronic liver disease, cardiovascular disease, kidney disease, and cancer.
Cysteine-rich with EGF-like domain protein 2 is a protein that in humans is encoded by the CRELD2 gene found on chromosome 22q13. It is a known homolog of CRELD1. CRELD2's identifying feature is a tryptophan-aspartic acid domain. It is a multifunctional glycoprotein that is approximately 60 kilodaltons and can reside in the endoplasmic reticulum (ER) or Golgi apparatus and be secreted spontaneously. It is implicated in numerous ER stress-related diseases including chronic liver disease, cardiovascular disease, kidney disease, and cancer.
== Structure == thumb|Structure of CRELD2 CRELD2 can present itself in a variety of isoforms with similar motifs but different functions.. Common motifs include EGF/calcium binding EGF domains and furin cysteine-rich domains. The C-terminal of this protein includes the following specific amino acid sequence necessary for retention and secretion: (R/H)EDL. The N-terminal has multiple CXXC motifs which are vital for translocation and isomerase activity. CpG islands are present in the functional promoter region upstream of CRELD2. In this functional promoter region, GC nucleotides are abundant, and a TATA box is absent. An ERSE (ER Stress Responsible Element) is also present in CRELD2 and is conserved in numerous species.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).