CYTH3

Also known as ARNO3, GRP1, PSCD3, cytohesin 3, cytohesin-3

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.

Gene data

CYTH3

Name: cytohesin 3
Type: protein-coding
Aliases: ARNO3, GRP1, PSCD3, cytohesin-3

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cytohesin 3

Symbol: CYTH3
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:6,148,751-6,272,677
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PSCD3 PDB 1bc9.png

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HomoloGene ID: 3116
exact match: identifiers.org/ncbigene/9265
genomic end: 6312275
genomic start: 6201407
cytogenetic location: 7p22.1

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Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.