CST4
Sign in to saveAlso known as cystatin S
Cystatin-S is a protein that in humans is encoded by the CST4 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to CST4, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 20.
Vinony links it to 5 Wikipedia language editions.
Gene data
CST4- Name
- cystatin S
- Type
- protein-coding
- Position
- 23,685,640–23,689,038 (−)
- Ensembl
- ENSG00000101441
- RefSeq RNA
- NM_001899.3
- RefSeq protein
- NP_001890.1
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
cystatin S
- Symbol
- CST4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:23,685,640-23,689,038
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1472
- genomic end
- 23689038
- genomic start
- 23666277
- chromosome
- human chromosome 20
- cytogenetic location
- 20p11.21
- expressed in
- thymus
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Cystatin-S is a protein that in humans is encoded by the CST4 gene.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function.
Excerpted from Wikipedia’s “CST4” article, available under the CC BY-SA 4.0 licence.