Structure via PubChem · Public domain (PubChem)
danthron
Sign in to saveAlso known as Dorbane, Istizin, 1,8-dihydroxy-9,10-anthracenedione, 1,8-dihydroxyanthra-9,10-quinone, 1,8-dihydroxy-9,10-anthraquinone, 1,8-Dihydroxyanthraquinone, Chrysazin
Dantron (INN), also known as chrysazin or 1,8-dihydroxyanthraquinone, is an orange-colored organic substance. Many structurally-related compounds are known. In terms of its molecular structure, it is related anthraquinone by the replacement of two hydrogen atoms by hydroxyl groups (–OH). It is used in some countries as a stimulant laxative.
In the Vinony graph
Within Vinony's link graph, danthron is referenced by 67 other articles, and connects out to laxative, United States and United Kingdom.
It is catalogued under topics including 3-Hydroxypropenals within hydroxyquinones, Dihydroxyanthraquinones and Drugboxes which contain changes to verified fields.
Its subject is documented across 9 Wikipedia language editions.
Chemical data
- Formula
- C14H8O4
- Molecular weight
- 240.21 g/mol
- IUPAC name
- 1,8-dihydroxyanthracene-9,10-dione
- SMILES
- C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
- InChIKey
- QBPFLULOKWLNNW-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 74.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- Constipation
via ChEMBL · EBI
Research
194 papers- Danthron attenuates experimental atherosclerosis by targeting foam cell formation.Experimental physiology · 2021
- Danthron.Report on carcinogens : carcinogen profiles · 2011
- Laxatives: replacing danthron.Drug and therapeutics bulletin · 1988
- Danthron suppresses autophagy and sensitizes pancreatic cancer cells to doxorubicin.Toxicology in vitro : an international journal published in association with BIBRA · 2019
- Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties.Antioxidants (Basel, Switzerland) · 2023
via PubMed
Wikidata facts
- Mass
- 240.042
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₄H₈O₄
- canonical SMILES
- C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
- World Health Organisation international non-proprietary name
- dantron
- found in taxon
- Asphodelus fistulosus
- defined daily dose
- 50
- subject has role
- carcinogen
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Medical uses
- Side effects
- See also
- References
Dantron (INN), also known as chrysazin or 1,8-dihydroxyanthraquinone, is an orange-colored organic substance. Many structurally-related compounds are known. In terms of its molecular structure, it is related anthraquinone by the replacement of two hydrogen atoms by hydroxyl groups (–OH). It is used in some countries as a stimulant laxative.
It should not be confused with ondansetron, an unrelated drug that was marketed in South Africa under the trade name "Dantron".
Excerpted from Wikipedia’s “danthron” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0