دانترون

Also known as Dorbane, Istizin, 1,8-dihydroxy-9,10-anthracenedione, 1,8-dihydroxyanthra-9,10-quinone, Danthron, 1,8-dihydroxy-9,10-anthraquinone, 1,8-Dihydroxyanthraquinone, Chrysazin

مركب كيميائي

In the Vinony graph

Vinony's link graph records 67 inbound references to دانترون, and connects out to laxative, United States and United Kingdom.

It sits within the topics 3-Hydroxypropenals within hydroxyquinones, Dihydroxyanthraquinones and Drugboxes which contain changes to verified fields.

Vinony links it to 9 Wikipedia language editions.

Chemical data

Formula: C14H8O4
Molecular weight: 240.21 g/mol
IUPAC name: 1,8-dihydroxyanthracene-9,10-dione
SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
InChIKey: QBPFLULOKWLNNW-UHFFFAOYSA-N
XLogP: 3.2
Polar surface area: 74.6 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Withdrawn

Max clinical phase: Approved
Molecule type: Small molecule
Indications: Constipation

via ChEMBL · EBI

Research

194 papers

Danthron attenuates experimental atherosclerosis by targeting foam cell formation.Experimental physiology · 2021
Danthron.Report on carcinogens : carcinogen profiles · 2011
Laxatives: replacing danthron.Drug and therapeutics bulletin · 1988
Danthron suppresses autophagy and sensitizes pancreatic cancer cells to doxorubicin.Toxicology in vitro : an international journal published in association with BIBRA · 2019
Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties.Antioxidants (Basel, Switzerland) · 2023

via PubMed

Wikidata facts

Mass: 240.042
Has use: medication

Show 6 more facts

chemical formula: C₁₄H₈O₄
canonical SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
World Health Organisation international non-proprietary name: dantron
found in taxon: Asphodelus fistulosus
defined daily dose: 50
subject has role: carcinogen

Sources (4)

via Wikidata · CC0

Article · العربية

دانترون (بالإنجليزية: Dantron)‏, يسمى أيضاً كريسازين أو 1,8 دي هدروكسي أنتراكينون, هو دواء يتكونبشكل أساسي من مادة عضوية مشتقة بشكل كبير من من وتنتج بعملية استبدال ذرتي بمجموعتي هدروكسيل.كما يجب عدم الخلطبينه وبين . يعد الدانترون دواء ملينا حيث يستعمل في بعض البلاد كمسهل.تم سحبه من السوق في العديد من البلدان نتيجة ارتفاع سميته.

Abstract from DBpedia / Wikipedia · CC BY-SA