Structure via PubChem · Public domain (PubChem)
dasatinib
Sign in to saveAlso known as BMS 345825, BMS 354825, BMS 35482513, Sprycel®, anh. dasatinib, dasatinib (anh.), anhydrous dasatinib, BMS-354825
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). It is taken by mouth.
Chemical data
- Formula
- C22H26ClN7O2S
- Molecular weight
- 488 g/mol
- IUPAC name
- N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
- SMILES
- CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
- InChIKey
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N
- XLogP
- 3.6
- Polar surface area
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
~9 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Adverse effects
- Pharmacology
- History
- Society and culture
- Legal status
- Economics
- Brand names
- Research
- Dasatinib+Quercetin
- References
- Further reading
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). It is taken by mouth.
Common adverse effects include low white blood cells, low blood platelets, anemia, swelling, rash, and diarrhea. Severe adverse effects may include bleeding, pulmonary edema, heart failure, and prolonged QT syndrome. Use during pregnancy may result in harm to the fetus. It is a tyrosine-kinase inhibitor and works by blocking a number of tyrosine kinases such as Bcr-Abl and the Src kinase family.
Excerpted from Wikipedia’s “dasatinib” article, available under the CC BY-SA 4.0 licence.