Desmin
Sign in to saveAlso known as DES, epididymis secretory sperm binding protein, intermediate filament protein, cardiomyopathy, dilated 1F (autosomal dominant), mutant desmin p.K241E, uniprot:P17661
Protein
Protein · UniProt
Desmin
- Gene
- DES
- Organism
- Homo sapiens (Human)
- Length
- 470 aa
- Molecular mass
- 53,536 Da
- Evidence
- 1: Evidence at protein level
Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, Pu…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- NAUNKNOWNRelationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and PrognosisMinistry of Scientific Research and Information Technology, Poland · NCT00819442
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P17661
via Wikidata · CC0
Article · Deutsch
Desmin (veralteter Name Skeletin) ist ein Typ 3-Intermediärfilament und damit ein Element des Zytoskeletts. Die Desminfilamente haben einen Durchmesser von 8–11 nm und eine speziesabhängige Molekülmasse von 50.000 bis 55.000 Dalton. Desmin kommt in der Skelett-, Herz- und glatten Muskulatur vor. Im Zytoplasma der Muskelfasern der quergestreiften Muskulatur verbindet es die Myofibrillen zu Bündeln und die sogenannten Z-Scheiben der Muskelfasern. Die Verbindung zwischen Desmin und den Z-Scheiben erfolgt durch ein spezifisches Intermediärfilament-assoziiertes Protein, dem Synemin. Desmin bindet an Syncoilin.
Abstract from DBpedia / Wikipedia · CC BY-SA