File:Diclofenac.svg · Wikimedia Commons · See Wikimedia Commons
Diclofenac
Sign in to saveAlso known as VOL458, CAT458, DSG318, CGP-45840B, GP-45840, [2-(2,6-dichloroanilino)phenyl]acetic acid, 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It can be taken orally (swallowed by mouth), inserted rectally as a suppository, injected intramuscularly, injected intravenously, applied to the skin topically, or through eye drops. Improvements in pain last up to eight hours. It is also available as the fixed-dose combination diclofenac/misoprostol (Arthrotec) to help protect the stomach; however, proton pump inhibitors such as omeprazole are typically first-line since they
OverviewAI-generated
Diclofenac is a chemical compound with the formula C₁₄H₁₁Cl₂NO₂. Its IUPAC name is 2-[2-(2,6-dichloroanilino)phenyl]acetic acid. The molecule has a mass of 295.017 and a weight of 296.1. It carries a charge of 0 and features an xlogp value of 4.4. The compound contains 2 hydrogen bond donors and 3 hydrogen bond acceptors, with a topological polar surface area of 49.3.
The substance is associated with the MCN code 2922.49.64. It is referenced by 743 other encyclopedia articles. Additionally, there are 17197 entries in the PubMed literature related to Diclofenac.
Synthesized by Vinony from 18 facts across 4 sources: Wikidata, PubChem, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 443636249
- Drug.image
- Diclofenac.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.caption
- Structure of diclofenac with ball and stick model
- Drug.image2
- Diclofenac-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.pronounce
- or
- Drug.tradename
- Voltaren, others
- Drug.MedlinePlus
- a689002
- Drug.DailyMedID
- Diclofenac
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- Oral, rectal, intramuscular, intravenous, topical, ophthalmic
- Drug.class
- Nonsteroidal anti-inflammatory drug (NSAID)
- Drug.ATC_prefix
- D11
via Wikipedia infobox
Chemical data
- Formula
- C14H11Cl2NO2
- Molecular weight
- 296.1 g/mol
- IUPAC name
- 2-[2-(2,6-dichloroanilino)phenyl]acetic acid
- SMILES
- C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
- InChIKey
- DCOPUUMXTXDBNB-UHFFFAOYSA-N
- XLogP
- 4.4
- Polar surface area
- 49.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
17,197 papers- Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls.ReviewClinical pharmacokinetics · 1997Davies NM, Anderson KEDOI: 10.2165/00003088-199733030-00003
- Diclofenac sodium.ReviewClinical pharmacy · 1989Small RE
- Effect of diclofenac on semen quality: A review.ReviewAndrologia · 2021Banihani SADOI: 10.1111/and.14021
- Diclofenac-potassium in migraine: a review.ReviewDrugs · 1999McNeely W, Goa KLDOI: 10.2165/00003495-199957060-00016
- Diclofenac epolamine (Flector) patch: evidence for topical activity.ReviewClinical drug investigation · 2009Petersen B, Rovati SDOI: 10.2165/0044011-200929010-00001
- Diclofenac sodium injection (Dyloject): in postoperative pain.ReviewDrugs · 2008McCormack PL, Scott LJDOI: 10.2165/00003495-200868010-00008
- Review of the safety of diclofenac/misoprostol.ReviewDrugs · 1993Gagnier PDOI: 10.2165/00003495-199300451-00008
- Diclofenac.Connecticut medicine · 1989Ogle C
via PubMed
~16 min read
Encyclopedic overview
16 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Heart
- Gastrointestinal
- Liver
- Kidney
- Mental health
- Pharmacology
- History
- Formulations and brand names
- {{anchor|Ecological problems}}Ecological effects
- Veterinary use
- Notes
- References
- External links
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It can be taken orally (swallowed by mouth), inserted rectally as a suppository, injected intramuscularly, injected intravenously, applied to the skin topically, or through eye drops. Improvements in pain last up to eight hours. It is also available as the fixed-dose combination diclofenac/misoprostol (Arthrotec) to help protect the stomach; however, proton pump inhibitors such as omeprazole are typically first-line since they are at least as effective as misoprostol, but with better tolerability.
Common side effects include abdominal pain, gastrointestinal bleeding, nausea, dizziness, headache, and swelling. Serious side effects may include heart disease, stroke, kidney problems, and stomach ulceration. Use is not recommended in the third trimester of pregnancy. It is likely safe during breastfeeding. Diclofenac is believed to work by decreasing the production of prostaglandins, like other drugs in this class.
Excerpted from Wikipedia’s “Diclofenac” article, available under the CC BY-SA 4.0 licence.