Structure via PubChem · Public domain (PubChem)
talampanel
Sign in to saveAlso known as GYKI 537773, LY-300164, LY300164
Talampanel (INN; development codes GYKI 537773 and LY300164) is a drug which has been investigated for the treatment of epilepsy, malignant gliomas, and amyotrophic lateral sclerosis (ALS).
Chemical data
- Formula
- C19H19N3O3
- Molecular weight
- 337.4 g/mol
- IUPAC name
- 1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
- SMILES
- C[C@@H]1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
- InChIKey
- JACAAXNEHGBPOQ-LLVKDONJSA-N
- XLogP
- 2.7
- Polar surface area
- 77.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- epilepsy, glioblastoma multiforme, oligoastrocytoma, anaplastic astrocytoma
via ChEMBL · EBI
Wikidata facts
- Mass
- 337.142641
Show 3 more facts
- chemical formula
- C₁₉H₁₉N₃O₃
- canonical SMILES
- CC1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
- isomeric SMILES
- C[C@@H]1CC2=CC3=C(C=C2C(=NN1C(=O)C)C4=CC=C(C=C4)N)OCO3
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Talampanel (INN; development codes GYKI 537773 and LY300164) is a drug which has been investigated for the treatment of epilepsy, malignant gliomas, and amyotrophic lateral sclerosis (ALS).
As of May 2010, results from the trial for ALS have been found negative. Talampanel is not currently under development.
Excerpted from Wikipedia’s “talampanel” article, available under the CC BY-SA 4.0 licence.