diphenoxylate

Also known as 4-ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester, ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylate, ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate, 2,2-diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile

Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridioides difficile infection.