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Dirlotapide
Sign in to saveDirlotapide is a drug used to treat obesity in dogs. It is manufactured by Pfizer and Zoetis and marketed under the brand name Slentrol.
Chemical data
- Formula
- C40H33F3N4O3
- Molecular weight
- 674.7 g/mol
- IUPAC name
- N-[(1S)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide
- SMILES
- CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)N[C@@H](C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
- InChIKey
- TUOSYWCFRFNJBS-BHVANESWSA-N
- XLogP
- 7.7
- Polar surface area
- 83.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- obesity
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 674.25
Show 5 more facts
- chemical formula
- C₄₀H₃₃F₃N₄O₃
- canonical SMILES
- CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)NC(C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
- isomeric SMILES
- CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)N[C@@H](C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
- medical condition treated
- obesity
- Commons category
- Dirlotapide
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Usage
- Regulation and safety
- References
Dirlotapide is a drug used to treat obesity in dogs. It is manufactured by Pfizer and Zoetis and marketed under the brand name Slentrol.
It works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor. This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption. It also elicits a satiety signal from lipid-filled cells lining the intestine.
Excerpted from Wikipedia’s “Dirlotapide” article, available under the CC BY-SA 4.0 licence.