Structure via PubChem · Public domain (PubChem)
DNQX
Sign in to saveDNQX (6,7-dinitroquinoxaline-2,3-dione) is a competitive antagonist at AMPA and kainate receptors, two ionotropic glutamate receptor (iGluR) subfamilies. It is used in a variety of molecular biology subfields, notably neurophysiology, to assist researchers in determining the properties of various types of ion channels and their potential applications in medicine.
Chemical data
- Formula
- C8H2N4O6
- Molecular weight
- 250.12 g/mol
- IUPAC name
- 6,7-dinitroquinoxaline-2,3-dione
- SMILES
- C1=C(C(=CC2=NC(=O)C(=O)N=C21)[N+](=O)[O-])[N+](=O)[O-]
- InChIKey
- YEUPBRRGMWBCEB-UHFFFAOYSA-N
- XLogP
- -0.7
- Polar surface area
- 151 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
1,155 papers- DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference.Brain research · 1995
- DNQX-induced toxicity in cultured rat hippocampal neurons: an apparent AMPA receptor-independent effect?Neurochemistry international · 2003
- Selective excitatory actions of DNQX and CNQX in rat thalamic neurons.Journal of neurophysiology · 2010
- Aniracetam and DNQX affect the acquisition of rapid tolerance to ethanol in mice.Pharmacology, biochemistry, and behavior · 2009
- DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex.Brain research · 1995
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 249.997
Show 3 more facts
- chemical formula
- C₈H₂N₄O₆
- canonical SMILES
- C1=C(C(=CC2=NC(=O)C(=O)N=C21)[N+](=O)[O-])[N+](=O)[O-]
- Commons category
- DNQX
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
DNQX (6,7-dinitroquinoxaline-2,3-dione) is a competitive antagonist at AMPA and kainate receptors, two ionotropic glutamate receptor (iGluR) subfamilies. It is used in a variety of molecular biology subfields, notably neurophysiology, to assist researchers in determining the properties of various types of ion channels and their potential applications in medicine.
DNQX (an AMPA receptor antagonist) displays significant effects on neurons. When applied to rat hippocampus neurons in culture, it produces a dose-dependent neurotoxicity which intriguingly seems to operate through a mechanism independent of ionotropic glutamate receptors. This effect is specific to neurons and does not impact the surrounding glial cells.
Excerpted from Wikipedia’s “DNQX” article, available under the CC BY-SA 4.0 licence.