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Org 26576
Sign in to saveAlso known as org-26576
ORG-26576 is an ampakine originally developed by Cortex Pharmaceuticals and then licensed to Organon International for development. In animal studies it has been shown to effectively potentiate AMPA receptor function, leading to increased BDNF release and enhanced neuronal differentiation and survival, as well as producing nootropic effects in standardised assays. Development as an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.
Chemical data
- Formula
- C11H12N2O2
- Molecular weight
- 204.22 g/mol
- IUPAC name
- (7S)-9-oxa-3,11-diazatricyclo[8.4.0.03,7]tetradeca-1(10),11,13-trien-2-one
- SMILES
- C1C[C@H]2COC3=C(C=CC=N3)C(=O)N2C1
- InChIKey
- FIKUEZUFASUKAH-QMMMGPOBSA-N
- XLogP
- 0.9
- Polar surface area
- 42.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 204.09
Show 3 more facts
- chemical formula
- C₁₁H₁₂N₂O₂
- canonical SMILES
- C1CC2COC3=C(C=CC=N3)C(=O)N2C1
- isomeric SMILES
- C1C[C@H]2COC3=C(C=CC=N3)C(=O)N2C1
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
ORG-26576 is an ampakine originally developed by Cortex Pharmaceuticals and then licensed to Organon International for development. In animal studies it has been shown to effectively potentiate AMPA receptor function, leading to increased BDNF release and enhanced neuronal differentiation and survival, as well as producing nootropic effects in standardised assays. Development as an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.
== See also == AMPA receptor positive allosteric modulator
Excerpted from Wikipedia’s “Org 26576” article, available under the CC BY-SA 4.0 licence.