Dynorphin A (1-13)

Chemical data

Formula

C75H126N24O15

Molecular weight

1604 g/mol

IUPAC name

6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)[C@H](CC3=CC=C(C=C3)O)N

InChIKey

OVVIBUHLQIYUEU-LCBAMVSPSA-N

XLogP

-4.2

Polar surface area

669 Ų

H-bond donors

22

H-bond acceptors

21

Formal charge

0

via PubChem

Drug data · ChEMBL

Molecule type

Protein

via ChEMBL · EBI

• Metabolism of dynorphin A(1-13).Die Pharmazie · 2004
• Metabolism of dynorphin A 1-13 in human blood and plasma.Pharmaceutical research · 1995
• Effects of dynorphin A(1-13) on opiate withdrawal in humans.Psychopharmacology · 1998
• Dynorphin a (1-13) alleviated stress-induced behavioral impairments in mice.Biological & pharmaceutical bulletin · 2014
• Multidimensional behavioral analyses show dynorphin A-(1-13) modulation of methamphetamine-induced behaviors in mice.European journal of pharmacology · 1992

via PubMed

Wikidata facts

Subclass of

dynorphin

Mass

1602.9834493319995

via Wikidata · CC0