Dynorphin A (1-13)

Also known as H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-DL-Lys-OH, YGGFLRRIRPKLK, Dynorphin A

chemical compound

In the Vinony graph

Vinony's link graph records 765 inbound references to Dynorphin A (1-13), and connects out to orexin, (+)-catechin and butorphanol.

Vinony links it to 7 Wikipedia language editions.

Formula: C75H126N24O15
Molecular weight: 1604 g/mol
IUPAC name: 6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)[C@H](CC3=CC=C(C=C3)O)N
InChIKey: OVVIBUHLQIYUEU-LCBAMVSPSA-N
XLogP: -4.2
Polar surface area: 669 Å²
H-bond donors: 22
H-bond acceptors: 21
Formal charge: 0

via PubChem

via ChEMBL · EBI

668 papers

Metabolism of dynorphin A(1-13).Die Pharmazie · 2004
Metabolism of dynorphin A 1-13 in human blood and plasma.Pharmaceutical research · 1995
Effects of dynorphin A(1-13) on opiate withdrawal in humans.Psychopharmacology · 1998
Dynorphin a (1-13) alleviated stress-induced behavioral impairments in mice.Biological & pharmaceutical bulletin · 2014
Multidimensional behavioral analyses show dynorphin A-(1-13) modulation of methamphetamine-induced behaviors in mice.European journal of pharmacology · 1992

Show 2 more facts

canonical SMILES: CCC(C)C(C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=C(C=C3)O)N
chemical formula: C₇₅H₁₂₆N₂₄O₁₅

Sources (2)

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