neurotensin

Also known as pro-neurotensin/neuromedin, neurotensin/neuromedin N, NT, NTS(151-163)

Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin was first isolated from extracts of bovine hypothalamus based on its ability to cause a visible vasodilation in the exposed cutaneous regions of anesthetized rats.

Key facts

Protein family.Symbol: Pro-NT_NN
Protein family.Name: Neurotensin/neuromedin N precursor
Protein family.caption: crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin
Protein family.Pfam: PF07421
Protein family.InterPro: IPR008055
Protein family.OPM family: 257
Protein family.OPM protein: 2oyv

via Wikipedia infobox

Chemical data

Formula: C78H121N21O20
Molecular weight: 1672.9 g/mol
IUPAC name: (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-4-carboxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-4-methyl-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]propanoyl]amino]butanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5
InChIKey: PCJGZPGTCUMMOT-ISULXFBGSA-N
XLogP: -3.7
Polar surface area: 674 Å²
H-bond donors: 21
H-bond acceptors: 23
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Protein

via ChEMBL · EBI

Research

6,349 papers

Neurotensin and energy balance.Journal of neurochemistry · 2023
Neurotensin and neurotensin receptors.Trends in pharmacological sciences · 1999
Neurotensin and pain modulation.Peptides · 2006
The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review.Cell communication and signaling : CCS · 2020
Neurotensin: A role in substance use disorder?Journal of psychopharmacology (Oxford, England) · 2016

via PubMed

Wikidata facts

Subclass of: peptide
Mass: 1671.909675

Show 5 more facts

chemical formula: C₇₈H₁₂₁N₂₁O₂₀
canonical SMILES: CCC(C)C(C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(C)C)NC(=O)C5CCC(=O)N5
found in taxon: Homo sapiens
isomeric SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5
exact match: www.uniprot.org/uniprot/P30990#PRO_0000019524

Sources (3)

via Wikidata · CC0

~7 min read

Encyclopedic overview

7 sections

Contents

Sequence and biosynthesis
Function
Regulation
Clinical significance
See also
References
External links

Neurotensin is distributed throughout the central nervous system, with highest levels in the hypothalamus, amygdala and nucleus accumbens. It induces a variety of effects, including analgesia, hypothermia, and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery, neurotensin is found in enteroendocrine cells of the small intestine, where it leads to pancreatic and biliary secretion, reduced gastric acid secretion, and smooth muscle contraction.

Excerpted from Wikipedia’s “neurotensin” article, available under the CC BY-SA 4.0 licence.

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