G protein-coupled receptors

large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and cellular responses

Rhodopsin, also known as visual purple, is a protein encoded by the RHO gene and a G-protein-coupled receptor (GPCR). It is a light-sensitive receptor protein that triggers visual phototransduction in rod cells. Rhodopsin mediates dim light vision and thus is extremely sensitive to light. When rhodopsin is exposed to light, it immediately photobleaches. In humans, it is fully regenerated in about 30 minutes, after which the rods are more sensitive. Defects in the rhodopsin gene cause eye diseases such as retinitis pigmentosa and congenital stationary night blindness.

class of G protein-coupled receptors

group of receptors to cannabinoid compounds

thumb|150px|Three-dimensional structure of cattle rhodopsin. The seven transmembrane domains are shown in varying colors. The chromophore is shown in red. thumb|right|400px|The retinal molecule inside an opsin protein absorbs a photon of light. Absorption of the photon causes retinal to change from its 11-cis-retinal isomer into its all-trans-retinal isomer. This change in shape of retinal pushes against the outer opsin protein to begin a signal cascade, which may eventually result in chemical signaling being sent to the brain as visual perception. The retinal is re-loaded by the body so that

receptors that respond to gamma-aminobutyric acid

mammalian protein found in Homo sapiens

Melanopsin is a type of photopigment belonging to a larger family of light-sensitive retinal proteins called opsins and encoded by the gene Opn4. In the mammalian retina, there are two additional categories of opsins, both involved in the formation of visual images: rhodopsin and photopsin (types I, II, and III) in the rod and cone photoreceptor cells, respectively.

mammalian protein found in Homo sapiens

type of cellular receptor that facilitates taste

class of four receptor proteins to the molecule adenosine

Type of membrance receptor that acts through a second messenger

mammalian protein found in Homo sapiens

P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors. This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. The P2Y12 receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

mammalian protein found in Homo sapiens

InterPro Family

protein-coding gene in the species Homo sapiens

receptor activated by peptide hormone GLP-1

InterPro Family

protein-coding gene in the species Homo sapiens

family of cell membrane receptors in almost all tissues

mammalian protein found in Homo sapiens

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

REDIRECT Vertebrate visual opsin#Cone opsins

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and va

Frizzled is a family of atypical G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. There are 10 known Frizzled receptor family members in humans. When activated, Frizzled leads to activation of Dishevelled in the cytosol.

InterPro Family

Cluster of differentiation 97 is a protein also known as BL-Ac[F2] encoded by the ADGRE5 gene. CD97 is a member of the adhesion G protein-coupled receptor (GPCR) family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

class of G protein-coupled receptors

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene. EMR2 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

protein-coding gene in the species Homo sapiens

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related peptide.

protein-coding gene in the species Homo sapiens

cell surface protein binding somatostatin and triggering intracellular changes

Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene.

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene.

Frizzled-9 (Fz-9) is a protein that in humans is encoded by the FZD9 gene. Fz-9 has also been designated as CD349 (cluster of differentiation 349).

protein-coding gene in the species Homo sapiens

ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.

GHB receptor coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

mammalian protein found in Homo sapiens

Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.

Vasoactive intestinal peptide receptor 2 also known as VPAC2, is a G-protein coupled receptor that in humans is encoded by the VIPR2 gene.

protein-coding gene in the species Homo sapiens

Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood and spleen, predominantly by myeloid cells.

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens

protein-coding gene in the species Homo sapiens