EI24
Sign in to saveAlso known as EPG4, PIG8, TP53I8, EI24, autophagy associated transmembrane protein, EI24 autophagy associated transmembrane protein
Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.
In the Vinony graph
Within Vinony's link graph, EI24 is referenced by 2 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 6 Wikipedia language editions.
Gene data
EI24- Name
- EI24 autophagy associated transmembrane protein
- Type
- protein-coding
- Position
- 125,536,608–125,585,035 (+)
- Aliases
- EPG4, PIG8, TP53I8
- Ensembl
- ENSG00000149547
- RefSeq RNA
- NM_001007277.1, NM_001290135.2, NM_001330419.2, NM_001437816.1, NM_001438416.1
- RefSeq protein
- NP_001277064.1, NP_001317348.1, NP_001424745.1, NP_001425345.1, NP_004870.3
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
EI24 autophagy associated transmembrane protein
- Symbol
- EI24
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:125,536,608-125,585,035
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 3588
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9538
- chromosome
- human chromosome 11
- genomic start
- 125569280
- genomic end
- 125584684
- cytogenetic location
- 11q24.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “EI24” article, available under the CC BY-SA 4.0 licence.