ENPP2

Name

ectonucleotide pyrophosphatase/phosphodiesterase 2

Type

protein-coding

Position

119,557,078–119,673,680 (−)

Aliases

ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2

Ensembl

ENSG00000136960

RefSeq RNA

NM_001040092.3, NM_001130863.3, NM_001330600.2, NM_006209.5, NR_045555.2

RefSeq protein

NP_001035181.1, NP_001124335.1, NP_001317529.1, NP_006200.3, XP_006716647.1

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008].

via MyGene.info

Gene · Ensembl

ectonucleotide pyrophosphatase/phosphodiesterase 2

Symbol

ENPP2

Biotype

Protein coding

Organism

Homo sapiens

Location

8:119,557,078-119,673,680

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

3nkr.png

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