Structure via PubChem · Public domain (PubChem)
ethamivan
Sign in to saveAlso known as Vandid, Etamivan
Etamivan (INN, or ethamivan (USAN); trade names Analepticon, Emivan, and Vandid) is a respiratory stimulant drug related to nikethamide. It was mainly used in the treatment of barbiturate overdose and chronic obstructive pulmonary disease, but has now largely fallen into disuse.
Chemical data
- Formula
- C12H17NO3
- Molecular weight
- 223.27 g/mol
- IUPAC name
- N,N-diethyl-4-hydroxy-3-methoxybenzamide
- SMILES
- CCN(CC)C(=O)C1=CC(=C(C=C1)O)OC
- InChIKey
- BQJODPIMMWWMFC-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 49.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- respiratory system disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 223.121
- Has use
- medication
Show 3 more facts
- chemical formula
- C₁₂H₁₇NO₃
- canonical SMILES
- CCN(CC)C(=O)C1=CC(=C(C=C1)O)OC
- Commons category
- Etamivan
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Etamivan (INN, or ethamivan (USAN); trade names Analepticon, Emivan, and Vandid) is a respiratory stimulant drug related to nikethamide. It was mainly used in the treatment of barbiturate overdose and chronic obstructive pulmonary disease, but has now largely fallen into disuse.
Adverse effects which are common to the respiratory stimulant class include sneezing, coughing, and laryngospasm when infused too rapidly. More serious adverse events include muscle twitching, tremors, and convulsions. The dose to treat barbiturate intoxication or carbon dioxide narcosis in adults ranges from 0.5 mg/kg to 5.0 mg/kg, infused intravenously over several minutes. Epilepsy and the use of monoamine oxidase inhibitors or other adrenergic drugs are contraindications.
Excerpted from Wikipedia’s “ethamivan” article, available under the CC BY-SA 4.0 licence.