Structure via PubChem · Public domain (PubChem)
Ethionamid
Sign in to saveAlso known as 1314 TH, ETP, ETH, 2-ethylthioisonicotinamide, etionamide, ethylisothiamide, 2-ethyl-4-thiopyridylamide
Arzneistoff
Chemical data
- Formula
- C8H10N2S
- Molecular weight
- 166.25 g/mol
- IUPAC name
- 2-ethylpyridine-4-carbothioamide
- SMILES
- CCC1=NC=CC(=C1)C(=S)N
- InChIKey
- AEOCXXJPGCBFJA-UHFFFAOYSA-N
- XLogP
- 1.1
- Polar surface area
- 71 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1965
- Admin. routes
- oral
- Indications
- osteomyelitis, multidrug-resistant tuberculosis, pulmonary tuberculosis, tuberculosis
via ChEMBL · EBI
Research
1,881 papers- Ethionamide.Tuberculosis (Edinburgh, Scotland) · 2008
- Ethionamide.Lancet (London, England) · 1960
- Ethionamide.British medical journal · 1960
- A review of the use of ethionamide and prothionamide in childhood tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2016
- Metabolism of the antituberculosis drug ethionamide.Current drug metabolism · 2013
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 166.056469
- Manufacturer
- Pfizer
- Has use
- medication
Show 7 more facts
- chemical formula
- C₈H₁₀N₂S
- World Health Organisation international non-proprietary name
- ethionamide
- canonical SMILES
- CCC1=NC=CC(=C1)C(=S)N
- medical condition treated
- tuberculosis
- Commons category
- Ethionamide
- defined daily dose
- 0.75
- subject has role
- bactericide
Sources (8)
via Wikidata · CC0
Article · Deutsch
Ethionamid ist ein Antibiotikum, das strukturell zu den Thionamiden zählt. Es wird zur Behandlung von multiresistenten Tuberkulose-Erregern eingesetzt. Es ist ein Wirkstoff der zweiten Wahl, die Anwendung erfolgt nur in Kombination mit anderen Antituberkulotika, da es bei alleiniger Gabe rasch zu Resistenzen kommt. Ethionamid wird von der Weltgesundheitsorganisation als unentbehrliches Arzneimittel geführt.
Abstract from DBpedia / Wikipedia · CC BY-SA