FG-7142
Sign in to saveFG-7142 (ZK-31906) is a drug of the β-carboline family which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor. It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and improves memory retention in animal studies.
Research
538 papers- β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish.Scientific reports · 2024
- FG 7142: is this validated tool to study anxiety now forgotten?Journal of neural transmission (Vienna, Austria : 1996) · 2020
- Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls.Psychopharmacology · 1988
- FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2007
- Benzodiazepine inverse agonist FG-7142-induced delayed behavioral depression in mice.Archives internationales de pharmacodynamie et de therapie · 1988
via PubMed
Wikidata facts
- Mass
- 225.09
Show 3 more facts
- canonical SMILES
- CNC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2
- chemical formula
- C₁₃H₁₁N₃O
- Commons category
- FG-7142
Sources (2)
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Article
2 sectionsContents
- See also
- References
FG-7142 (ZK-31906) is a drug of the β-carboline family which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor. It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and improves memory retention in animal studies.
==See also== Substituted β-carboline
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