Structure via PubChem · Public domain (PubChem)
FG-7142
Sign in to saveFG-7142 (ZK-31906) is a drug of the β-carboline family which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor. It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and improves memory retention in animal studies.
Chemical data
- Formula
- C13H11N3O
- Molecular weight
- 225.25 g/mol
- IUPAC name
- N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide
- SMILES
- CNC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2
- InChIKey
- QMCOPDWHWYSJSA-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 57.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
538 papers- β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish.Scientific reports · 2024
- FG 7142: is this validated tool to study anxiety now forgotten?Journal of neural transmission (Vienna, Austria : 1996) · 2020
- Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls.Psychopharmacology · 1988
- FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2007
- Benzodiazepine inverse agonist FG-7142-induced delayed behavioral depression in mice.Archives internationales de pharmacodynamie et de therapie · 1988
via PubMed
Wikidata facts
- Mass
- 225.09
Show 4 more facts
- canonical SMILES
- CNC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2
- chemical formula
- C₁₃H₁₁N₃O
- subject has role
- nootropic
- Commons category
- FG-7142
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
FG-7142 (ZK-31906) is a drug of the β-carboline family which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor. It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and improves memory retention in animal studies.
==See also== Substituted β-carboline
Excerpted from Wikipedia’s “FG-7142” article, available under the CC BY-SA 4.0 licence.