Structure via PubChem · Public domain (PubChem)
fludiazepam
Sign in to saveAlso known as Erispan, 7-chloro-5-(O-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one, Fludiazepamum
Fludiazepam, marketed under the brand name Erispan (エリスパン) is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam, originally developed by Hoffmann-La Roche in the 1960s. It is marketed in Japan and Taiwan. It exerts its pharmacological properties via enhancement of GABAergic inhibition. Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Fludiazepam has been used recreationally.
Chemical data
- Formula
- C16H12ClFN2O
- Molecular weight
- 302.73 g/mol
- IUPAC name
- 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
- SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F
- InChIKey
- ROYOYTLGDLIGBX-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- anxiety
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 302.062219
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₆H₁₂ClFN₂O
- canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F
- Commons category
- Fludiazepam
- defined daily dose
- 0.75
- subject has role
- anxiolytic
- MCN code
- 2933.91.31
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
Fludiazepam, marketed under the brand name Erispan (エリスパン) is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam, originally developed by Hoffmann-La Roche in the 1960s. It is marketed in Japan and Taiwan. It exerts its pharmacological properties via enhancement of GABAergic inhibition. Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Fludiazepam has been used recreationally.
== See also == Diazepam Diclazepam (the 2ʹ-chloro analog) Difludiazepam (the 2',6'-difluoro derivative) Flunitrazepam (the 7-nitro analog) Flualprazolam (the triazolo derivative) Ro20-8552
Excerpted from Wikipedia’s “fludiazepam” article, available under the CC BY-SA 4.0 licence.