fluspirilene

Fluspirilene (Redeptin, Imap, R6218) is a diphenylbutylpiperidine typical antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly. It was discovered at Janssen Pharmaceutica in 1963. A 2007 systematic review investigated the efficacy of fluspirilene decanoate for people with schizophrenia: {| class="wikitable" |+ Fluspirilene decanoate compared to oral antipsychotics |- ! Summary |- |Participant numbers in each comparison were small so power to identify clear difference is limited. Randomized controlled trial data identified no clear differences between the long-acting injection of fluspirilene and oral medication for outcomes that include adverse effects. |- | style="padding:0;" | {| class="wikitable collapsible collapsed" style="width:100%;" |- ! scope="col" style="text-align: left;"| Outcome ! scope="col" style="text-align: left;"| Findings in words ! scope="col" style="text-align: left;"| Findings in numbers ! scope="col" style="text-align: left;"| Quality of evidence |- ! colspan="4" style="text-align: left;"| Global outcome |- | Leaving the study earlyFollow up: 6 weeks to 5 months || Fluspirilene decanoate may increase the risk of leaving the study (reasons not specified), but, the difference is not clear between people given fluspirilene decanoate and those receiving oral antipsychotics. These findings are based on data of low quality. || RR 1.18 (0.08 to 16.78) || Low |- ! colspan="4" style="text-align: left;"| Mental state |- | RelapseFollow up: 6 weeks to 5 months || Using the depot, long-acting fluspirilene decanoate makes little difference for the outcome of 'relapse' compared with those receiving oral antipsychotics - at least for those willing to be engaged with trials. These findings are based on data of low quality. || RR 1.18 (0.08 to 16.78) || Low |- ! colspan="4" style="text-align: left;"| Adverse effects |- | Needing anticholinergic drugsFollow up: 6 weeks to 5 months || The depot fluspirilene decanoate does not seem to cause any more movement disorders - for which anticholinergic drugs are used - compared with oral antipsychotics. These findings are based on data of low quality. || RR 0.07 (0.00 to 1.07) || Low |- | Dizziness || Fluspirilene decanoate may reduce the chance of experiencing dizziness compared with the oral antipsycotics. Data are based on low quality evidence. || RR 0.59 (0.37 to 0.95) || Low |- ! colspan="4" style="text-align: left;"| Missing outcomes |- | || Data on quality of life, and service use (e.g. hospitalization) were not reported in trials.|| || |- |} |}

==See also== Pimozide Penfluridol Spirodecanone Spiperone Mosapramine (atypical antipsychotic)