Structure via PubChem · Public domain (PubChem)
fluvastatin
Sign in to saveAlso known as XUO320, Canef®, Lescol®, (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid, (+)-(3R,5S)-fluvastatin
Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.
Chemical data
- Formula
- C24H26FNO4
- Molecular weight
- 411.5 g/mol
- IUPAC name
- (E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
- SMILES
- CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
- InChIKey
- FJLGEFLZQAZZCD-MCBHFWOFSA-N
- XLogP
- 3.5
- Polar surface area
- 82.7 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
2,370 papers- Fluvastatin: A Choice for COVID-19-associated Mucormycosis Management.Current medicinal chemistry · 2024
- Fluvastatin for lowering lipids.The Cochrane database of systematic reviews · 2018
- Fluvastatin.Expert opinion on pharmacotherapy · 2002
- Clinical pharmacokinetics of fluvastatin.Clinical pharmacokinetics · 2001
- Fluvastatin treatment is not associated with an increased incidence of cancer.International journal of clinical practice · 2006
via PubMed
Wikidata facts
- Mass
- 411.185
- Has use
- medication
Show 9 more facts
- significant drug interaction
- bezafibrate
- chemical formula
- C₂₄H₂₆FNO₄
- defined daily dose
- 60
- medical condition treated
- hypercholesterolemia
- canonical SMILES
- CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)O)O)O)C3=CC=C(C=C3)F
- isomeric SMILES
- CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
- World Health Organisation international non-proprietary name
- fluvastatin
- Commons category
- Fluvastatin
- physically interacts with
- 3-hydroxy-3-methylglutaryl-CoA reductase
Sources (7)
via Wikidata · CC0
~3 min read
Encyclopedic overview
9 sectionsContents
- Adverse effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacodynamics
- Pharmacokinetics
- Names
- Research
- References
Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.
It was patented in 1982 and approved for medical use in 1994. It is on the World Health Organization's List of Essential Medicines.
Excerpted from Wikipedia’s “fluvastatin” article, available under the CC BY-SA 4.0 licence.