fluvastatin

Also known as XUO320, Canef®, Lescol®, (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid, (+)-(3R,5S)-fluvastatin

Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.

Chemical data

Formula: C24H26FNO4
Molecular weight: 411.5 g/mol
IUPAC name: (E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
InChIKey: FJLGEFLZQAZZCD-MCBHFWOFSA-N
XLogP: 3.5
Polar surface area: 82.7 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

2,370 papers

Fluvastatin: A Choice for COVID-19-associated Mucormycosis Management.Current medicinal chemistry · 2024
Fluvastatin for lowering lipids.The Cochrane database of systematic reviews · 2018
Fluvastatin.Expert opinion on pharmacotherapy · 2002
Clinical pharmacokinetics of fluvastatin.Clinical pharmacokinetics · 2001
Fluvastatin treatment is not associated with an increased incidence of cancer.International journal of clinical practice · 2006

via PubMed

Wikidata facts

Mass: 411.185

Show 6 more facts

chemical formula: C₂₄H₂₆FNO₄
defined daily dose: 60
canonical SMILES: CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)O)O)O)C3=CC=C(C=C3)F
isomeric SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
World Health Organisation international non-proprietary name: fluvastatin
Commons category: Fluvastatin

Sources (7)

via Wikidata · CC0

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