Structure via PubChem · Public domain (PubChem)
فوسآپرپیتانت
Sign in to saveAlso known as Ivemend®, MK-0517, L-758,298, L-758298, Fosaprepitantum, Fosaprepitant
Fosaprepitant, sold under the brand names Emend (US) and Ivemend (EU) among others, is an antiemetic medication, administered intravenously. It is a prodrug of aprepitant.
Chemical data
- Formula
- C23H22F7N4O6P
- Molecular weight
- 614.4 g/mol
- IUPAC name
- [5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-3-oxo-1H-1,2,4-triazol-2-yl]phosphonic acid
- SMILES
- C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F
- InChIKey
- BARDROPHSZEBKC-OITMNORJSA-N
- XLogP
- 1
- Polar surface area
- 124 Ų
- H-bond donors
- 3
- H-bond acceptors
- 14
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2008
- Admin. routes
- parenteral
- Indications
- Chemotherapy-induced nausea and vomiting, multiple myeloma, Nausea and vomiting, brain injury
via ChEMBL · EBI
Research
269 papers- Fosaprepitant for postoperative nausea and vomiting in patients undergoing laparoscopic gastrointestinal surgery: a randomised trial.British journal of anaesthesia · 2023
- Aprepitant, fosaprepitant and risk of ifosfamide-induced neurotoxicity: a systematic review.Cancer chemotherapy and pharmacology · 2022
- The clinical research study for fosaprepitant to prevent chemotherapy-induced nausea and vomiting: A review.Advances in clinical and experimental medicine : official organ Wroclaw Medical University · 2023
- Fosaprepitant Dimeglumine: A Review in the Prevention of Nausea and Vomiting Associated with Chemotherapy.Drugs · 2016
- Aprepitant and fosaprepitant drug interactions: a systematic review.British journal of clinical pharmacology · 2017
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 614.117
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₃H₂₂F₇N₄O₆P
- Commons category
- Fosaprepitant
- canonical SMILES
- CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F
- isomeric SMILES
- C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F
- World Health Organisation international non-proprietary name
- fosaprepitant
- subject has role
- NK1 receptor antagonists
via Wikidata · CC0
Available in 8 languages
via Wikidata sitelinks · CC0