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GeneQ18025012· pop 6· linked from 486 articles

GABBR1

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Also known as GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2, gamma-aminobutyric acid type B receptor subunit 1

Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

Gene data

GABBR1

Name: gamma-aminobutyric acid type B receptor subunit 1
Type: protein-coding
Position: 29,552,554–29,633,976 (−)
Aliases: GABABR1, GABBR1-3, GB1, GPRC3A, NEDLC
Ensembl: ENSG00000237112
RefSeq RNA: NM_001319053.2, NM_001470.4, NM_021903.3, NM_021904.4, NM_021905.2
RefSeq protein: NP_001305982.1, NP_001461.1, NP_068703.1, NP_068704.2, XP_005249039.1

This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016].

Gene Ontology

Biological process

osteoblast differentiation G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway gamma-aminobutyric acid signaling pathway gamma-aminobutyric acid signaling pathway gamma-aminobutyric acid signaling pathway gamma-aminobutyric acid signaling pathway

Molecular function

G protein-coupled receptor activity G protein-coupled GABA receptor activity G protein-coupled GABA receptor activity G protein-coupled GABA receptor activity G protein-coupled GABA receptor activity G protein-coupled GABA receptor activity G protein-coupled GABA receptor activity protein binding

Cellular component

extracellular region cytoplasm endoplasmic reticulum membrane plasma membrane plasma membrane plasma membrane plasma membrane synaptic vesicle

Pathways

cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)GABAergic synapse - Homo sapiens (human)Taste transduction - Homo sapiens (human)Estrogen signaling pathway - Homo sapiens (human)GnRH secretion - Homo sapiens (human)Morphine addiction - Homo sapiens (human)Neurotransmitter receptors and postsynaptic signal transmission Transmission across Chemical Synapses Neuronal System

via MyGene.info

Gene · Ensembl

gamma-aminobutyric acid type B receptor subunit 1

Symbol: GABBR1
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr HSCHR6_MHC_DBB_CTG1:821,155-898,710
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein GABBR1 PDB 1srz.png

Show 5 more facts

HomoloGene ID: 1132
exact match: identifiers.org/ncbigene/2550
genomic start: 29523406
genomic end: 29601753
cytogenetic location: 6p22.1

Sources (5)

via Wikidata · CC0

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Article

6 sections

Contents

Function
Interactions
See also
References
Further reading
External links

Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

== Function ==

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Categories

Genes on human chromosome 6 G protein-coupled receptors