گالانتامین

Key facts

Drug.Watchedfields

changed

Drug.caption2

3D representation of a galantamine molecule

Drug.class

Acetylcholinesterase inhibitor

Drug.verifiedrevid

461118063

Drug.image

Galantamine.svg

Drug.image_class

skin-invert-image

Drug.caption

Molecular structure of galantamine

Drug.image2

Galantamine_3D_Ball-and-Stick.png

Drug.image_class2

bg-transparent

Drug.width2

276

Drug.tradename

Razadyne, others

Drug.MedlinePlus

a699058

Drug.DailyMedID

Razadyne

Drug.pregnancy_AU

B1

Drug.metabolism

Liver partially CYP450:CYP2D6/3A4 substrate

Drug.elimination_half life

7 hours

Drug.excretion

Kidney (95%, of which 32% unchanged), fecal (5%)

Drug.IUPHAR_ligand

6693

via Wikipedia infobox

Chemical data

Formula

C17H21NO3

Molecular weight

287.35 g/mol

IUPAC name

(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol

SMILES

CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O

InChIKey

ASUTZQLVASHGKV-JDFRZJQESA-N

XLogP

1.8

Polar surface area

41.9 Ų

H-bond donors

1

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

2001

Admin. routes

oral

Indications

Fish-eye disease, obesity, nicotine dependence, subarachnoid hemorrhage

via ChEMBL · EBI

• Galantamine for dementia due to Alzheimer's disease and mild cognitive impairment.The Cochrane database of systematic reviews · 2024
• Galantamine beyond Alzheimer's disease-a fact or artefact?CNS spectrums · 2022
• Galantamine-Memantine combination in the treatment of Alzheimer's disease and beyond.Psychiatry research · 2020
• Galantamine in Alzheimer's disease.Expert review of neurotherapeutics · 2008
• Galantamine ameliorates experimental pancreatitis.Molecular medicine (Cambridge, Mass.) · 2023

via PubMed

Wikidata facts

Has part

carbon

Mass

287.152

Has use

medication

via Wikidata · CC0