acetylcholinesterase
Sign in to saveAlso known as apoptosis-related acetylcholinesterase, Yt blood group, acetylcholinesterase (Yt blood group), ACHE
Acetylcholinesterase (AChE) acetylcholine acetylhydrolase, also known as AChase or acetylhydrolase, is the primary type of cholinesterase in the body, coded for in the human by the gene ACHE. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters:
Key facts
- Enzyme.Name
- acetylcholinesterase
- Enzyme.EC_number
- 3.1.1.7
- Enzyme.CAS_number
- 9000-81-1
- Enzyme.GO_code
- 0003990
- Enzyme.image
- The reaction catalyzed by acetylcholinesterase.tif
- Enzyme.caption
- Acetylcholinesterase catalyzes the hydrolysis of acetylcholine to acetate ion and choline
via Wikipedia infobox
Protein · UniProt
Acetylcholinesterase
- Gene
- ACHE
- Organism
- Homo sapiens (Human)
- Length
- 614 aa
- Molecular mass
- 67,796 Da
- Evidence
- 1: Evidence at protein level
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
54 registered- PHASE3TERMINATEDStudy of the Safety and Effectiveness of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's DiseaseFORUM Pharmaceuticals Inc · NCT01969123
- PHASE3COMPLETEDA Study of the Effectiveness and Safety of Galantamine Hydrobromide on Cognitive Impairment in Patients With Schizophrenia.Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · NCT00077727
- PHASE1COMPLETEDSafety, Tolerability, and Pharmacokinetics of ABT-354 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase InhibitorsAbbVie · NCT01908010
- PHASE2NOT_YET_RECRUITINGAn Open Trial of a Novel Pharmacotherapy for Habit Modification in Anorexia NervosaNew York State Psychiatric Institute · NCT06518941
- PHASE2TERMINATEDSafety and Tolerability Study Evaluating a New Treatment for Subjects With Mild to Moderate Alzheimer's DiseaseAbbVie (prior sponsor, Abbott) · NCT01690195
- RECRUITINGSerum Cholinesterases, Paraoxonase, and Cardiovascular Risk After Intravitreal BevacizumabAtaturk University · NCT07550777
Wikidata facts
- Instance of
- protein
Show 3 more facts
- found in taxon
- Homo sapiens
- cell component
- basement membrane
- topic's main category
- Category:Anticholinesterases
Sources (7)
via Wikidata · CC0
~10 min read
Encyclopedic overview
15 sectionsContents
- Enzyme structure and mechanism
- Species
- Biological function
- Disease relevance
- Distribution
- AChE gene
- AChE<sub>T</sub>
- AChE<sub>H</sub>
- AChE<sub>R</sub>
- Nomenclature
- Inhibitors
- See also
- References
- Further reading
- External links
Acetylcholinesterase (AChE) acetylcholine acetylhydrolase, also known as AChase or acetylhydrolase, is the primary type of cholinesterase in the body, coded for in the human by the gene ACHE. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters: acetylcholine + H2O = choline + acetate
It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate cholinergic synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Excerpted from Wikipedia’s “acetylcholinesterase” article, available under the CC BY-SA 4.0 licence.