acetylcholinesterase
Acetylcholinesterase (AChE) acetylcholine acetylhydrolase, also known as AChase or acetylhydrolase, is the primary type of cholinesterase in the body, coded for in the human by the gene ACHE. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters:
Key facts
- Enzyme.Name
- acetylcholinesterase
- Enzyme.EC_number
- 3.1.1.7
- Enzyme.CAS_number
- 9000-81-1
- Enzyme.GO_code
- 0003990
- Enzyme.image
- The reaction catalyzed by acetylcholinesterase.tif
- Enzyme.caption
- Acetylcholinesterase catalyzes the hydrolysis of acetylcholine to acetate ion and choline
via Wikipedia infobox
Article
15 sectionsContents
- Enzyme structure and mechanism
- Species
- Biological function
- Disease relevance
- Distribution
- AChE gene
- AChE<sub>T</sub>
- AChE<sub>H</sub>
- AChE<sub>R</sub>
- Nomenclature
- Inhibitors
- See also
- References
- Further reading
- External links
Acetylcholinesterase (AChE) acetylcholine acetylhydrolase, also known as AChase or acetylhydrolase, is the primary type of cholinesterase in the body, coded for in the human by the gene ACHE. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters: acetylcholine + H2O = choline + acetate
It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate cholinergic synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.