globosidi
Also known as globosides
thumb|right|120px|N-Acetylgalactosamine|N-Acetylgalactosamine thumb|Sphingosine Globosides (also known as globo-series glycosphingolipids) are a sub-class of the lipid class glycosphingolipid with three to nine sugar molecules as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. One characteristic of globosides is that the "core" sugars consists of Glucose-Galactose-Galactose (Ceramide-βGlc4-1βGal4-1αGal), like in the case of the most basic globoside, globotriaosylceramide (Gb3), also known as pk-antigen. Another i
Research
934 papers- Globoside Is an Essential Intracellular Factor Required for Parvovirus B19 Endosomal Escape.Cells · 2024
- Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier.PLoS pathogens · 2023
- Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection.Journal of virology · 2019
- Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages.Frontiers in immunology · 2022
- Globoside accelerates the differentiation of dental epithelial cells into ameloblasts.International journal of oral science · 2016
via PubMed
Article · Italiano
I globosidi sono un tipo di glicosfingolipidi neutri (non dotati di carica) con due o più zuccheri, di solito D-glucosio, D-galattosio o N-acetil-D-galattosammina situati nella catena laterale. Un glicosfingolipide che ha un solo zucchero come catena laterale è chiamato cerebroside. La catena laterale può essere scissa dagli enzimi galattosidasi e glucosidasi. La carenza di α-galattosidasi A, causa la malattia di Fabry, una malattia metabolica ereditaria caratterizzata dall'accumulo del globoside globotriaosilceramide. Struttura di un Globoside
Abstract from DBpedia / Wikipedia · CC BY-SA