GOLT1B
Sign in to saveAlso known as GCT2, GOT1, GOT1B, YMR292W, CGI-141, golgi transport 1B
Vesicle transport protein GOT1B is a protein that in humans is encoded by the GOLT1B gene.
Gene data
GOLT1B- Name
- golgi transport 1B
- Type
- protein-coding
- Aliases
- CGI-141, GCT2, GOT1, GOT1B, YMR292W
Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in endoplasmic reticulum. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 41102
- exact match
- identifiers.org/ncbigene/51026
- genomic end
- 21671342
- genomic start
- 21654715
- cytogenetic location
- 12p12.1
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Vesicle transport protein GOT1B is a protein that in humans is encoded by the GOLT1B gene.
Got1p is a protein that aides in vesicle transport through the Golgi apparatus of the cell. Got1p has a calculated mass of 15.4 kDa and consists of 138 residues. It is believed that the protein is a tetra-spanning membrane protein, and is evolutionarily conserved. Homologes of the protein have been found in Caenorhabditis elegans, Plasmodium falciparum, and in mammals. GOT1 is normally associated closely with Sf2p (encoded by sft2), which is another protein of similar function. In vivo, It has been found that the removal of these two proteins results in defects in endosome-Golgi traffic and ER-Golgi traffic. In vitro, the removal of got1 specifically, results in a defect in ER-Golgi transport in relation to vesicle tethering to Golgi membranes. The exact contribution that the protein has towards vesicle tethering is still a mystery, however, it is suspected that Got1p is involved in the release of Ca2+ in the Golgi membranes, causing ion channels associated with vesicle tethering to be affected.