GPR183

Also known as EBI2, G protein-coupled receptor 183, hEBI2

Gene data

GPR183

Name: G protein-coupled receptor 183
Type: protein-coding
Aliases: EBI2, hEBI2

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

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HomoloGene ID: 28066
exact match: identifiers.org/ncbigene/1880
genomic start: 99294539
genomic end: 99307399
cytogenetic location: 13q32.3

Sources (4)

via Wikidata · CC0

~6 min read

Article

8 sections

Contents

Tissue distribution and function
B cells
T cells
Dendritic cells
Ligand
Virus infection
References
Further reading

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein (GPCR) expressed on the surface of some immune cells, namely B cells and T cells; in humans it is encoded by the GPR183 gene. Expression of EBI2 is one critical mediator of immune cell localization within lymph nodes, responsible in part for the coordination of B cell, T cell, and dendritic cell movement and interaction following antigen exposure. EBI2 is a receptor for oxysterols. The most potent activator is 7α,25-dihydroxycholesterol (7α,25-OHC), with other oxysterols exhibiting varying affinities for the receptor. Oxysterol gradients drive chemotaxis, attracting the EBI2-expressing cells to locations of high ligand concentration. The GPR183 gene was identified due to its upregulation during Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41, hence its name: EBI2.

== Tissue distribution and function ==