Skip to content
Vinony
English
EnglishDeutschEspañolFrançaisItalianoNederlandsPortuguêsSvenska
GeneQ18026418· pop 5· linked from 489 articles

GPR37

Sign in to save

Also known as EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene. GPR37 is primarily found in the central nervous system (CNS), with significant expression observed in various CNS regions including the amygdala, basal ganglia (caudate, putamen, and nucleus accumbens), substantia nigra, hippocampus, frontal cortex, and hypothalamus, particularly noteworthy is its exceptionally elevated expression in the spinal cord.

Gene data

GPR37
Name
G protein-coupled receptor 37
Type
protein-coding
Position
124,743,885–124,766,099 (−)
Aliases
EDNRBL, PAELR, hET(B)R-LP
Ensembl
ENSG00000170775
RefSeq RNA
NM_005302.5
RefSeq protein
NP_005293.1

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012].

Gene Ontology

Pathways

Parkinson disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptorsGPCR downstream signallingG alpha (i) signalling eventsGPCR ligand bindingParkin-Ubiquitin Proteasomal System pathway

via MyGene.info

Gene · Ensembl

G protein-coupled receptor 37

Symbol
GPR37
Biotype
Protein coding
Organism
Homo sapiens
Location
7:124,743,885-124,766,099
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
3875
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/2861
expressed in
inferior olivary nucleus
genomic end
124765792
genomic start
124743885
chromosome
human chromosome 7
cytogenetic location
7q31.33
Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

3 sections
Contents
  • Interactions
  • References
  • Further reading

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene. GPR37 is primarily found in the central nervous system (CNS), with significant expression observed in various CNS regions including the amygdala, basal ganglia (caudate, putamen, and nucleus accumbens), substantia nigra, hippocampus, frontal cortex, and hypothalamus, particularly noteworthy is its exceptionally elevated expression in the spinal cord.

== Interactions ==

Excerpted from Wikipedia’s “GPR37” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0