GRWD1
Sign in to saveAlso known as CDW4, GRWD, RRB1, WDR28, glutamate-rich WD repeat containing 1, glutamate rich WD repeat containing 1
Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein (containing five WD40 repeat motifs) that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin accessibility and loading of the MCM helicase. GRWD1 has also been shown to play a critical role in ribosome biogenesis.
In the Vinony graph
Vinony's link graph records 3 inbound references to GRWD1, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 19.
Vinony links it to 5 Wikipedia language editions.
Gene data
GRWD1- Name
- glutamate rich WD repeat containing 1
- Type
- protein-coding
- Position
- 48,445,512–48,458,382 (+)
- Aliases
- CDW4, DIAR14, GRWD, RRB1, WDR28
- Ensembl
- ENSG00000105447
- RefSeq RNA
- NM_031485.4
- RefSeq protein
- NP_113673.3
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
glutamate rich WD repeat containing 1
- Symbol
- GRWD1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:48,445,512-48,458,382
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- exact match
- identifiers.org/ncbigene/83743
- HomoloGene ID
- 6644
- found in taxon
- Homo sapiens
- genomic end
- 48960279
- genomic start
- 48445841
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.33
- expressed in
- granulocyte
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Role in cancer
- References
- Further reading
Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein (containing five WD40 repeat motifs) that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin accessibility and loading of the MCM helicase. GRWD1 has also been shown to play a critical role in ribosome biogenesis.
== Role in cancer == While some ribosomal proteins like RPL5 and RPL11 are suggested to act as tumor suppressors by inhibiting E3 ubiquitin-protein ligase MDM2 and thus activating p53, others, such as GRWD1, may promote tumorigenesis. Overexpression of GRWD1 suppresses p53 and transforms normal cells, possibly through its interaction with RPL11, preventing it from regulating MDM2.
Excerpted from Wikipedia’s “GRWD1” article, available under the CC BY-SA 4.0 licence.