GRWD1
Sign in to saveAlso known as CDW4, GRWD, RRB1, WDR28, glutamate-rich WD repeat containing 1, glutamate rich WD repeat containing 1
Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein (containing five WD40 repeat motifs) that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin accessibility and loading of the MCM helicase. GRWD1 has also been shown to play a critical role in ribosome biogenesis.
Gene data
GRWD1- Name
- glutamate rich WD repeat containing 1
- Type
- protein-coding
- Aliases
- CDW4, DIAR14, GRWD, RRB1, WDR28
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012].
via MyGene.info
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/83743
- HomoloGene ID
- 6644
- genomic end
- 48960279
- genomic start
- 48445841
- cytogenetic location
- 19q13.33
Sources (4)
via Wikidata · CC0
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Article
3 sectionsContents
- Role in cancer
- References
- Further reading
Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein (containing five WD40 repeat motifs) that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin accessibility and loading of the MCM helicase. GRWD1 has also been shown to play a critical role in ribosome biogenesis.
== Role in cancer == While some ribosomal proteins like RPL5 and RPL11 are suggested to act as tumor suppressors by inhibiting E3 ubiquitin-protein ligase MDM2 and thus activating p53, others, such as GRWD1, may promote tumorigenesis. Overexpression of GRWD1 suppresses p53 and transforms normal cells, possibly through its interaction with RPL11, preventing it from regulating MDM2.