H2AC14

Also known as H2A/E, H2AFE, dJ160A22.4, histone cluster 1, H2aj, histone cluster 1 H2A family member j, H2A clustered histone 14, HIST1H2AJ

Histone H2A type 1-J is a protein that in humans is encoded by the HIST1H2AJ gene.

Gene data

H2AC14

Name: H2A clustered histone 14
Type: protein-coding
Position: 27,814,302–27,814,777 (−)
Aliases: H2A/E, H2AFE, HIST1H2AJ, dJ160A22.4
Ensembl: ENSG00000276368
RefSeq RNA: NM_021066.3
RefSeq protein: NP_066544.1

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].

Pathways

Necroptosis - Homo sapiens (human)Neutrophil extracellular trap formation - Homo sapiens (human)Alcoholism - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 88882
exact match: identifiers.org/ncbigene/8331
genomic end: 27814777
genomic start: 27814302
cytogenetic location: 6p22.1

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Histone H2A type 1-J is a protein that in humans is encoded by the HIST1H2AJ gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.