HCN4
Sign in to saveAlso known as SSS2, hyperpolarization activated cyclic nucleotide gated potassium channel 4, BRGDA8, EIG18
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.
Gene data
HCN4- Name
- hyperpolarization activated cyclic nucleotide gated potassium channel 4
- Type
- protein-coding
- Aliases
- BRGDA8, EIG18, SSS2
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].
via MyGene.info
Gene · Ensembl
hyperpolarization activated cyclic nucleotide gated potassium channel 4
- Symbol
- HCN4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:73,319,859-73,368,958
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HCN4 PDB 1q3e.png
Show 9 more facts
- genetic association
- atrial fibrillation
- HomoloGene ID
- 3997
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10021
- genomic end
- 73368958
- genomic start
- 73612200
- chromosome
- human chromosome 15
- cytogenetic location
- 15q24.1
- Commons category
- HCN4 channel
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.
There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. Some humans with bradycardia and Sick sinus syndrome have been shown to have mutations in their HCN4 gene. The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.
Excerpted from Wikipedia’s “HCN4” article, available under the CC BY-SA 4.0 licence.