RELA
Sign in to saveAlso known as NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.
Gene data
RELA- Name
- RELA proto-oncogene, NF-kB subunit
- Type
- protein-coding
- Position
- 65,653,599–65,663,138 (−)
- Aliases
- AIF3BL3, CMCU, NFKB3, p65
- Ensembl
- ENSG00000173039
- RefSeq RNA
- NM_001145138.2, NM_001243984.2, NM_001243985.2, NM_001404657.1, NM_001404658.1
- RefSeq protein
- NP_001138610.1, NP_001230913.1, NP_001230914.1, NP_001391586.1, NP_001391587.1
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
RELA proto-oncogene, NF-kB subunit
- Symbol
- RELA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,653,599-65,663,138
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~12 min read
Encyclopedic overview
17 sectionsContents
- Gene and expression
- Structure
- Phosphorylation
- Acetylation
- Methylation
- Interactions
- Role in immune system
- Cancer
- Prostate
- Thyroid
- Leukemia
- Head and neck
- Breast
- Monogenic Behçet's Disease-like conditions
- References
- Further reading
- External links
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.
RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation. NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer.
Excerpted from Wikipedia’s “RELA” article, available under the CC BY-SA 4.0 licence.