E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.
E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).