HERC5

Also known as CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5

E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.

Gene data

HERC5

Name: HECT and RLD domain containing E3 ubiquitin protein ligase 5
Type: protein-coding
Aliases: CEB1, CEBP1

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021].

via MyGene.info

Wikidata facts

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HomoloGene ID: 81848
exact match: identifiers.org/ncbigene/51191
genomic start: 88457119
cytogenetic location: 4q22.1
genomic end: 89427314

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E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.