RNF14
Sign in to saveAlso known as ARA54, HFB30, TRIAD2, HRIHFB2038, ring finger protein 14
E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.
Gene data
RNF14- Name
- ring finger protein 14
- Type
- protein-coding
- Aliases
- ARA54, HFB30, HRIHFB2038, TRIAD2
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 129170
- exact match
- identifiers.org/ncbigene/9604
- genomic start
- 141337893
- genomic end
- 141990292
- cytogenetic location
- 5q31.3
Sources (4)
via Wikidata · CC0
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Article
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.
== Function ==