hexobendine

Hexobendine is a vasodilator that acts as an adenosine reuptake inhibitor.

Research

141 papers

[Studies on the pharmacokinetics of hexobendine in rats. I. Distribution following i.v. administration (author's transl)].Arzneimittel-Forschung · 1975
[Review of the literature and report of experiments relating to the coronaroactive drug, hexobendine].Minerva cardioangiologica · 1972
[Influence of hexobendine, prenylamine and verapamil on the contractile response of isolated rabbit left atria and aortae to calcium (author's transl)].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 1977
[Effects of hexobendine on adenosine metabolism and myocardial energy metabolism (author's transl)].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 1978
[Clinical experience with N,N'-dimethyl-N,N'-bis-(3-(3',4',5'-trimethoxybenzoyloxy)-propyl)-ethylenediamine dihydrochloride (hexobendine)].Arzneimittel-Forschung · 1968

via PubMed

Wikidata facts

Mass: 592.3

Show 2 more facts

chemical formula: C₃₀H₄₄N₂O₁₀
canonical SMILES: CN(CCCOC(=O)C1=CC(=C(C(=C1)OC)OC)OC)CCN(C)CCCOC(=O)C2=CC(=C(C(=C2)OC)OC)OC

Sources (2)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

Synthesis
See also
References

Hexobendine is a vasodilator that acts as an adenosine reuptake inhibitor.

==Synthesis== Hexobendine can be synthesized starting with a reaction between 3,4,5-trimethoxybenzoyl chloride (1) and 3-chloropropanol (2) to give the corresponding ester, 3-chloropropyl 3,4,5-trimethoxybenzoate (3). The last step involves the reaction between two molar equivalents of 3 with one molar equivalent of 1,2-dimethylethylenediamine (4) completing the synthesis of hexobendine (5). thumb|500px|left| Synthesis of hexobendine