Histamine receptor H2

Protein · UniProt

Histamine H2 receptor

Gene

HRH2

Organism

Homo sapiens (Human)

Length

359 aa

Molecular mass

40,098 Da

Evidence

1: Evidence at protein level

G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels (PubMed:38647423, PubMed:39333117). This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransm…

• NACOMPLETED
  Histamine H1/H2 Receptors and Training AdaptationsUniversity Ghent · NCT04450134
• PHASE1COMPLETED
  Impact of a Histamine H2 Receptor Antagonist (H2RA) on the Pharmacokinetics (PK) of Telaglenastat in Healthy SubjectsCalithera Biosciences, Inc · NCT04540965
• NACOMPLETED
  The Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R AntagonistSecond Affiliated Hospital of Xi'an Jiaotong University · NCT06313307
• COMPLETED
  Effect of H2 Receptor Antagonist and Proton Pump Inhibitor on the Positivity Rates and Clinical Outcomes of COVID-19Seoul National University Hospital · NCT04834752
• NACOMPLETED
  Proton Pump Inhibitor Versus Histamine-2 Receptor Antagonist for the Prevention of Recurrent Peptic UlcersKaohsiung Veterans General Hospital. · NCT02551744
• PHASE3COMPLETED
  ASP (PPI_H2RA) Study-H2RA Versus PPI for the Prevention of Recurrent UGIB in High-risk Users of Low-dose ASAChinese University of Hong Kong · NCT01408186

via ClinicalTrials.gov

Wikidata facts

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