Structure via PubChem · Public domain (PubChem)
lavoltidine
Sign in to saveAlso known as loxtidine
Lavoltidine (INN, USAN, BAN; previously known as loxtidine; development code AH-23,844) is a highly potent and selective H2 receptor antagonist which was under development by Glaxo Wellcome (now GlaxoSmithKline) as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents.
Chemical data
- Formula
- C19H29N5O2
- Molecular weight
- 359.5 g/mol
- IUPAC name
- [1-methyl-5-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]-1,2,4-triazol-3-yl]methanol
- SMILES
- CN1C(=NC(=N1)CO)NCCCOC2=CC=CC(=C2)CN3CCCCC3
- InChIKey
- VTLNPNNUIJHJQB-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 75.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1 papers- Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.Pharmacology & therapeutics · 1997
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 359.232
Show 5 more facts
- chemical formula
- C₁₉H₂₉N₅O₂
- canonical SMILES
- CN1C(=NC(=N1)CO)NCCCOC2=CC=CC(=C2)CN3CCCCC3
- Commons category
- Lavoltidine
- World Health Organisation international non-proprietary name
- lavoltidine
- subject has role
- H2 antagonists
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Lavoltidine (INN, USAN, BAN; previously known as loxtidine; development code AH-23,844) is a highly potent and selective H2 receptor antagonist which was under development by Glaxo Wellcome (now GlaxoSmithKline) as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents.
==See also== H2 receptor antagonist Sufotidine (analogous sequence in which a sulfonyl group replaces the hydroxyl group)
Excerpted from Wikipedia’s “lavoltidine” article, available under the CC BY-SA 4.0 licence.