pizotyline

Also known as SMG105, BC-105, pizotifan, pizotifen

Pizotifen, also known as pizotyline and sold under the brand names Sandomigran and Mosegor among others, is an antimigraine agent of the tricyclic group which is used primarily as a preventative to reduce the frequency of recurrent migraine headaches.

Key facts

Drug.Verifiedfields: verified
Drug.verifiedrevid: 464208411
Drug.IUPAC_name: 4-(1-methyl-4-piperidylidine)-9,10-dihydro -4H-benzo-[4,5]cyclohepta[1,2]-thiophene
Drug.image: Pizotifen structure.svg
Drug.image_class: skin-invert-image
Drug.width: 180px
Drug.tradename: Sandomigran, Mosegor, Litec, others
Drug.pregnancy_AU: B1
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_UK: POM
Drug.routes_of_administration: Oral
Drug.bioavailability: 78%
Drug.protein_bound: >90%
Drug.metabolism: N-Glucuronidation
Drug.onset: 5 hours ()
Drug.elimination_half life: 23 hours
Drug.excretion: 18% feces, 55% urine (both as metabolites)

via Wikipedia infobox

Research

450 papers

Migraine.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1988
Uremic pruritus.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 1996
Pizotyline effectively attenuates the stimulus effects of N-methyl-3,4-methylenedioxyamphetamine (MDMA).Pharmacology, biochemistry, and behavior · 2005
Pizotyline-induced cholestatic jaundice.Archives of internal medicine · 1984
Serotonin antagonists.Australian and New Zealand journal of medicine · 1984

via PubMed

~6 min read

Encyclopedic overview

15 sections

Contents

Medical uses
Migraine headaches
Other uses
Contraindications
Adverse effects
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
History
Society and culture
Names
Availability
References
External links

==Medical uses== ===Migraine headaches=== The main medical use for pizotifen is for the prevention of migraine and cluster headache. Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid, cyproheptadine and amitriptyline. While pizotifen is effective in adults, evidence of efficacy in children is limited, and its use is limited by side effects, principally drowsiness and weight gain, and it is usually not the first choice medicine for preventing migraines, instead being used as an alternative when other drugs have failed to be effective. It is not effective in relieving migraine attacks once in progress.

Excerpted from Wikipedia’s “pizotyline” article, available under the CC BY-SA 4.0 licence.

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