HLA-F
Sign in to saveAlso known as CDA12, HLA-5.4, HLA-CDA12, HLAF, major histocompatibility complex, class I, F
HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the HLA-F gene. It is an empty intracellular molecule that encodes a non-classical heavy chain anchored to the membrane and forming a heterodimer with a β-2 microglobulin light chain. It belongs to the HLA class I heavy chain paralogues that separate from most of the HLA heavy chains. HLA-F is localized in the endoplasmic reticulum and Golgi apparatus, and is also unique in the sense that it exhibits few polymorphisms in the human population relative to the other HLA genes; however, there have been
Gene data
HLA-F- Name
- major histocompatibility complex, class I, F
- Type
- protein-coding
- Position
- 29,722,738–29,740,358 (+)
- Aliases
- CDA12, HLA-5.4, HLA-CDA12, HLAF
- Ensembl
- ENSG00000137403
- RefSeq RNA
- NM_001098478.2, NM_001098479.2, NM_018950.3, XM_011514564.2, XM_017010810.1
- RefSeq protein
- NP_001091948.1, NP_001091949.1, NP_061823.2, XP_011512866.1, XP_016866299.1
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
major histocompatibility complex, class I, F
- Symbol
- HLA-F
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_SSTO_CTG1:1,029,074-1,044,770
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 133121
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3134
- chromosome
- human chromosome 6
- genomic start
- 29690552
- genomic end
- 29706305
- cytogenetic location
- 6p22.1
Sources (3)
via Wikidata · CC0
~13 min read
Encyclopedic overview
19 sectionsContents
- HLA-F
- Gene
- Protein
- Structure
- Expression
- Intracellular expression
- Extracellular expression
- Expression during pregnancy
- Interaction with NK cells
- Transcriptional regulation of HLA-F
- Function
- Association with specialized ligands
- Maternal immunity tolerance
- Intermolecular communication
- Exogenous antigen cross-presentation
- Ligand during inflammatory response
- Disease association
- References
- Further reading
HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the HLA-F gene. It is an empty intracellular molecule that encodes a non-classical heavy chain anchored to the membrane and forming a heterodimer with a β-2 microglobulin light chain. It belongs to the HLA class I heavy chain paralogues that separate from most of the HLA heavy chains. HLA-F is localized in the endoplasmic reticulum and Golgi apparatus, and is also unique in the sense that it exhibits few polymorphisms in the human population relative to the other HLA genes; however, there have been found different isoforms from numerous transcript variants found for the HLA-F gene. Its pathways include IFN-gamma signaling and CDK-mediated phosphorylation (cyclin-dependent kinase) and removal of the Saccharomyces cerevisiae Cdc6 protein, which is crucial for functional DNA replication.
== HLA-F ==
Excerpted from Wikipedia’s “HLA-F” article, available under the CC BY-SA 4.0 licence.