HLA-DQA2

Also known as DX-ALPHA, HLA-DXA, HLA-DQA2 (gene), major histocompatibility complex, class II, DQ alpha 2, HLADQA2, DC-alpha, HLA-DCA, DQA1

HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leukocyte antigen system.

Gene data

HLA-DQA2

Name: major histocompatibility complex, class II, DQ alpha 2
Type: protein-coding
Chromosome: HSCHR6_MHC_QBL_CTG1
Position: 3,935,606–3,941,465 (+)
Aliases: DC-alpha, DQA1, DX-ALPHA, HLA-DCA, HLA-DXA, HLADQA2
Ensembl: ENSG00000231526
RefSeq RNA: NM_020056.5
RefSeq protein: NP_064440.1

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010].

Gene Ontology

Biological process

peptide antigen assembly with MHC class II protein complex immune response immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of immune response positive regulation of T cell activation

Molecular function

protein binding MHC class II protein complex binding MHC class II receptor activity peptide antigen binding

Cellular component

Golgi membrane lysosomal membrane lysosomal membrane lysosomal membrane endoplasmic reticulum membrane Golgi apparatus plasma membrane plasma membrane

Pathways

Phagosome - Homo sapiens (human)Cell adhesion molecules - Homo sapiens (human)Antigen processing and presentation - Homo sapiens (human)Hematopoietic cell lineage - Homo sapiens (human)Th1 and Th2 cell differentiation - Homo sapiens (human)Th17 cell differentiation - Homo sapiens (human)Intestinal immune network for IgA production - Homo sapiens (human)Type I diabetes mellitus - Homo sapiens (human)Leishmaniasis - Homo sapiens (human)Toxoplasmosis - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

major histocompatibility complex, class II, DQ alpha 2

Symbol: HLA-DQA2
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr HSCHR6_MHC_COX_CTG1:4,055,484-4,160,989
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

3 sections

Contents

COVID-19
References
Further reading

The protein encoded by this gene is expressed, but unlike HLA-DQA1, it is apparently unable to heterodimerize with HLA class II beta chain paralogues. The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.

Excerpted from Wikipedia’s “HLA-DQA2” article, available under the CC BY-SA 4.0 licence.