HLA-DRB1
Sign in to saveAlso known as DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1, major histocompatibility complex, class II, DR beta 1
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of rheumatoid arthritis.
Gene data
HLA-DRB1- Name
- major histocompatibility complex, class II, DR beta 1
- Type
- protein-coding
- Position
- 32,577,902–32,589,848 (−)
- Aliases
- DRB1, HLA-DR1B, HLA-DRB, SS1
- Ensembl
- ENSG00000229074
- RefSeq RNA
- NM_001243965.1, NM_001359193.1, NM_001359194.1, NM_002124.4, XM_024452553.2
- RefSeq protein
- NP_001230894.1, NP_001346122.1, NP_001346123.1, NP_002115.2, XP_024308321.1
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
major histocompatibility complex, class II, DR beta 1
- Symbol
- HLA-DRB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_DBB_CTG1:3,814,543-3,848,645
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 1AQD.png
Show 8 more facts
- HomoloGene ID
- 136635
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3123
- genomic end
- 32557625
- genomic start
- 32577902
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.32
- expressed in
- right coronary artery
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Gene structure and polymorphisms
- Gene expression
- See also
- References
- Further reading
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. DRB1 alleles, especially those encoding amino acid sequence changes at positions 11 and 13, are associated risk of rheumatoid arthritis.
== Function == The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins to T helper cells. Class II molecules are constitutively expressed in professional antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages), and could be induced in non-professional APCs.
Excerpted from Wikipedia’s “HLA-DRB1” article, available under the CC BY-SA 4.0 licence.