major histocompatibility complex, class I, G

Also known as HLA G antigen, mutant MHC class Ib antigen, b2 microglobulin, HLA-G, HLA-G histocompatibility antigen, class I, G, MHC class I antigen G, HLA class I histocompatibility antigen, alpha chain G, mutant MHC class I antigen

HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the HLA-G gene.

Protein · UniProt

HLA class I histocompatibility antigen, alpha chain G

Gene: HLA-G
Organism: Homo sapiens (Human)
Length: 338 aa
Molecular mass: 38,224 Da
Evidence: 1: Evidence at protein level

Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:19304799, PubMed:23184984, PubMed:29262349). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (P…

3D-structureAlternative splicingCell membraneCell projectionDisulfide bondEndoplasmic reticulumEndosomeGlycoprotein

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

3 registered

COMPLETED
Beta-2 Microglobulin and Serum Cytokines x HAARTUPECLIN HC FM Botucatu Unesp · NCT00831207
COMPLETED
Crabmeat and Health StudyUniversity of Aberdeen · NCT03104530
NACOMPLETED
Molecule Removal and Ease of Use: A Comparison of Two Different DialyzersVantive Health LLC · NCT00636389

via ClinicalTrials.gov

Wikidata facts

Instance of: major histocompatibility complex
Image: Protein HLA-G PDB 1ydp.png

Show 1 more fact

found in taxon: Homo sapiens

Sources (5)

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~9 min read

Encyclopedic overview

12 sections

Contents

Structure
Function
Pregnancy
Parasitic Infections
Cancer
Allergy
Interactions
HLA-G as a Clinical Target
Immune Checkpoint Inhibitors
CAR T-cell Therapy
References
Further reading

HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the HLA-G gene.

HLA-G belongs to the HLA nonclassical class I heavy chain paralogues. Classical HLA I proteins are found on all nucleated cells and express peptides in their peptide binding groove. They can express "self" peptides when the cell is healthy as well as foreign peptides when the cell is infected by a parasite or cancer. HLA-G is a nonclassical protein and serves a different function from classical HLA class I molecules, but it still expresses a nine amino acid peptide in its peptide binding groove. The third and ninth amino acid in the peptide sequence serve as anchor residues, and are thus conserved in all the peptides HLA-G bind to.

Excerpted from Wikipedia’s “major histocompatibility complex, class I, G” article, available under the CC BY-SA 4.0 licence.

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