HLA-E
Sign in to saveAlso known as EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E
HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the HLA-E gene. The human HLA-E is a non-classical MHC class I molecule that is characterized by a limited polymorphism and a lower cell surface expression than its classical paralogues. The functional homolog in mice is called Qa-1b, officially known as H2-T23.
Gene data
HLA-E- Name
- major histocompatibility complex, class I, E
- Type
- protein-coding
- Position
- 30,489,503–30,494,205 (+)
- Aliases
- HLA-6.2, QA1
- Ensembl
- ENSG00000204592
- RefSeq RNA
- NM_005516.6, XM_017010807.2, XM_054329806.1, XM_054330294.1, XM_054330589.1
- RefSeq protein
- NP_005507.3, XP_016866296.1, XP_054185781.1, XP_054186269.1, XP_054186564.1
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
major histocompatibility complex, class I, E
- Symbol
- HLA-E
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:30,489,495-30,494,205
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- HLA-E.png
Show 5 more facts
- HomoloGene ID
- 134018
- exact match
- identifiers.org/ncbigene/3133
- genomic start
- 30489509
- genomic end
- 30494194
- cytogenetic location
- 6p22.1
Sources (3)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Structure
- Function
- References
- Further reading
HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the HLA-E gene. The human HLA-E is a non-classical MHC class I molecule that is characterized by a limited polymorphism and a lower cell surface expression than its classical paralogues. The functional homolog in mice is called Qa-1b, officially known as H2-T23.
== Structure ==